Effect of Polysorbate - 80 on Oritavancin Binding to Plastic Surfaces – 1 Implications for Susceptibility Testing
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Effect of Polysorbate-80 on Oritavancin Binding to Plastic Surfaces – 1 Implications for Susceptibility Testing 2 3 4 Running Title: Polysorbate-80 effect on oritavancin binding 5 6 7 Francis F. Arhin 1 , Ingrid Sarmiento 1 , Adam Belley 1 , Geoffrey A. M c Kay 1 , Deborah C. Draghi 2 , 8 Parveen Grover 2 , Daniel F. Sahm 2 , Thomas R. Parr Jr. 1 and Gregory Moeck 1* 9 10 Targanta Therapeutics, Saint Laurent, Québec, Canada 1 and Eurofins Medinet, Herndon, 11 Virginia, USA 2 12 13 14 15 16 17 *Corresponding author. Mailing Address: Department of Biology, Targanta Therapeutics 18 7170 Frederick Banting Street, Second Floor, Saint Laurent, Québec, Canada H4S 2A1. 19 Phone: (514) 332-1008 ext 232. Fax: (514) 332-6033. E-mail: [email protected] 20 21 22 23 AC CE PT ED Copyright © 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.01513-07 AAC Accepts, published online ahead of print on 25 February 2008
منابع مشابه
Effect of polysorbate 80 on oritavancin binding to plastic surfaces: implications for susceptibility testing.
Oritavancin, a semisynthetic lipoglycopeptide with activity against gram-positive bacteria, has multiple mechanisms of action, including the inhibition of cell wall synthesis and the perturbation of the membrane potential. Approved guidelines for broth microdilution MIC assays with dalbavancin, another lipoglycopeptide, require inclusion of 0.002% polysorbate 80. To investigate the potential im...
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تاریخ انتشار 2008